Keesense

An end-to-end service

The various vital parameters collected by the connected medical device t-shirt are automatically and securely transmitted to the patient’s smartphone application via Bluetooth. In order to minimize the patient’s stress, he/she can only access his/her physical activity data (number of steps). The data is then routed to a web interface, allowing our partners to retrieve the collected information and integrate it into their own data analysis platform.

Chronolife’s solution enables healthcare professionals to intervene before any significant deterioration in the patient’s health status thanks to its continuous monitoring and customizable alerts transmitted by the remote monitoring platform. With faster care and timely medical attention, Keesense allows patients to safely recover at home and reduce unnecessary hospital readmission, saving them from expensive hospitalization costs.

Thanks to its fully interoperable platform, Chronolife provides an end-to-end service, allowing healthcare professionals to receive personalized alerts and dashboards via one of our remote monitoring platform partners. The RPM platform integrates patient raw data as well as our pre-treated health indicators, collected through the Keesense medical device, to provide an optimized interface for patient management, data visualization as well as analysis. Healthcare professionals can monitor multiple patients at the same time, while optimizing costs. In addition, the alert system supports healthcare professionals in their diagnosis and decision making regarding the associated treatment.

Remote Patient Monitoring

RPM is Becoming a Healthcare Mainstay

Spurred by the COVID-19 pandemic, healthcare professionals are increasingly providing patients with remote patient monitoring devices (RPM). These wearable sensors monitor chronic conditions outside of a healthcare setting, which can help keep a watchful eye on conditions from high blood sugar to heart rate.

While the transition to RPM was accelerated by the need to keep patients away from locations experiencing high COVID-19 transmission, it was also fueled by patients’ desires to avoid multiple doctor’s visits, which can cut hours out of their days. Patients tend to be more receptive to RPM when the technology fits seamlessly into their lifestyles, as patients consider intrusiveness a cost, and factor significantly in their adoption decisions.

Chronolife’s Keesense RPM allows medical staff to oversee patients remotely via data transmitted by a smart shirt to an app via Bluetooth. The wearable allows for the continuous monitoring of six physiological parameters — electrocardiogram, heart rate, physical activity, respiration, skin temperature, and pulmonary impedance to detect edemas. The data from the t-shirt is then sent to a secure and certified server for live or time-delayed analysis by the user’s healthcare team. The t-shirt is designed for comfort and is reusable and washable.

COVID-19

Keesense: our medical grade wearable for COVID patient monitoring

Benefits of Connected Medical Devices for COVID Patients

During the COVID-19 pandemic, Remote Patient Monitoring (RPM) has been creatively utilized to detect early warning signs, monitor patients at home (to preserve bed space at hospitals), and conduct post-discharge follow-up for COVID-19 “long-haulers.”

According to a Kaiser Permanente study, RPM for COVID-19 patients was very effective in preventing hospital admissions and improving recovery from the virus. Researchers found that only 10% of the 13,055 patients studied with access to the RPM kit were admitted to the hospital and only 0.2% of those patients died while participating. These patients tended to be 60 or older with existing comorbidities, such as obesity or hypertension.

Researchers at Harvard Medical School reported similar findings regarding COVID-19 RPM programs and noted that they allow health professionals to track the health status of COVID patients in the comfort of their home environments, which reduces hospital utilization. They also found that RPM significantly reduced readmissions for these patients.

Chronolife’s Keesense Product for COVID-19 Remote Monitoring

Keesense is a connected medical device (CE Class IIa) in the form of a t-shirt which allows a real-life measurement of multiple physiological parameters, including key vital signs for tracking COVID-19 symptoms such as respiration, temperature, and electrocardiogram. The analysis of original indicators around HRV (Heart Rate Variability) and nocturnal heart rate allows a more precise and continuous respiratory follow-up. The simultaneous analysis of these different indicators can thus help health professionals in their diagnosis.

All smart sensors are fully integrated into the machine washable t-shirt that is worn just like any everyday garment, therefore making it very comfortable and easy to use for COVID-19 patients.

Therapeutic Efficiency Programs

The Role of Remote Patient Monitoring in Pharma Digital Transformation

Virtual, Decentralized Clinical Trials

Clinical-trial decentralization existed in certain cases before the COVID-19 pandemic, but the crisis accelerated virtualization in both consumer and trial contexts. McKinsey surveys noted that up to 98 percent of patients reported satisfaction with telemedicine, while 72 percent of physicians reported similar or better experiences with remote engagement compared with in-person visits.

GlobalData recently conducted a survey to indicate how the pharmaceutical and healthcare industry is working on the issue of clinical trial disruptions amid the pandemic. According to the survey, 17% of the respondents adopted RPM (Remote Patient Monitoring) to deal with clinical trial disruptions, while another 15% intend to switch to decentralized clinical trials. About 14% were in favor of remote site initiation visits, while 13% of the companies asked research staff to work remotely.

How RPM Facilitates Therapeutic Efficiency

When the threat of COVID-19 passes, many expect RPM to remain a critical element in therapeutic efficiency programs. According to experts who spoke with The Scientist, remote approaches offer sponsors and investigators multiple advantages, from efficiency and cost effectiveness to improved patient compliance and datasets. RPM reduces the time commitment for patients taking part in the trials, which many hope can help the “democratization of clinical trials” to enable diverse representation of study participants across demographics, regions, and a variety of cohort factors.

The U.S. Food and Drug Administration (FDA), for example, is encouraging a faster transition to RPM to maintain oversight of clinical sites. RPM reduces the expenses associated with launching a clinical trial. The technology requires less travel from participants, conserves site resources and reduces burnout and turnover among those participating.

Chronolife’s Keesense RPM Solution for Therapeutic Efficiency

Keesense is a connected medical device (CE Class IIa) in the form of a machine washable, wearable t-shirt which allows continuous, real-life monitoring of multiple physiological parameters. The vital signs data collected by Keesense can be automatically and securely transmitted to healthcare providers for them to track patients’ response to medical treatment programs, enable dosage optimization and regimen recalibration in real time.

Worn like any other everyday garment without needing to maintain the smart sensors, Keesense greatly encourages participant compliance and reduces drop-out rates throughout the virtual clinical trial process or digital therapy services. More importantly, unlike other wearables that require patients to take a reading, Chronolife’s smart t-shirt automatically and continuously records multiple medical measurements, guaranteeing continuous data integrity and accuracy.

Thanks to its multiparametric capabilities and its end-to-end model, Keesense enables pharmaceuticals to virtually collect, visualize and analyze clinical trial participants’ physiological data via one of our remote monitoring platform partners, allowing them to monitor a large number of decentralized remote patients at the same time regardless of physical barriers.